What is gene therapy,Gene therapy techniques,Challenges of gene therapy,Avoiding the immune response,The cost of gene therapy

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What is gene therapy?
Gene therapy is when DNA is introduced into a patient to treat a genetic disease. The new DNA usually contains a functioning gene to correct the effects of a disease-causing mutation.Gene therapy uses sections of DNA? (usually genes?) to treat or prevent disease.
·  The DNA is carefully selected to correct the effect of a mutated gene that is causing disease.
·  The technique was first developed in 1972 but has, so far, had limited success in treating human diseases.
· Gene therapy may be a promising treatment option for some genetic diseases?, including muscular dystrophy? and cystic fibrosis?.
·     There are two different types of gene therapy depending on which types of cells are treated:
 Somatic gene therapy: transfer of a section of DNA to any cell of the body that doesn’t produce sperm or eggs. Effects of gene therapy will not be passed onto the patient’s children.
o                  Germline gene therapy: transfer of a section of DNA to cells that produce eggs or sperm. Effects of gene therapy will be passed onto the patient’s children and subsequent generations.
Gene therapy techniques
There are several techniques for carrying out gene therapy. These include:

  1. Gene augmentation therapy

·     This is used to treat diseases caused by a mutation that stops a gene from producing a functioning product, such as a protein?.
·                     This therapy adds DNA containing a functional version of the lost gene back into the cell.
·                     The new gene produces a functioning product at sufficient levels to replace the protein that was originally missing.
·                     This is only successful if the effects of the disease are reversible or have not resulted in lasting damage to the body.
·                     For example, this can be used to treat loss of function disorders such as cystic fibrosis by introducing a functional copy of the gene to correct the disease (see illustration below).

  • Gene inhibition therapy

·  Suitable for the treatment of infectious diseases, cancer and inherited disease caused by inappropriate gene activity.
  • ·  The aim is to introduce a gene whose product either:
  •  inhibits the expression of another gene
  • interferes with the activity of the product of another gene.

  • ·     The basis of this therapy is to eliminate the activity of a gene that encourages the growth of disease-related cell
  • For example, cancer is sometimes the result of the over-activation of an oncogene? (gene which stimulates cell growth). So, by eliminating the activity of that oncogene through gene inhibition therapy, it is possible to prevent further cell growth and stop the cancer in its tracks. 
Killing of specific cells
  • ·Suitable for diseases such as cancer that can be treated by destroying certain groups of cells.
  • ·The aim is to insert DNA into a diseased cell that causes that cell to die.

·                     This can be achieved in one of two ways:
  •           the inserted DNA contains a “suicide” gene that produces a highly toxic product which kills the diseased cell
  •            the inserted DNA causes expression of a protein that marks the cells so that the diseased cells are attacked by the body’s natural immune system.
  • ·            It is essential with this method that the inserted DNA is targeted appropriately to avoid the death of cells that are functioning normally.

How is DNA transfer done?
·                     A section of DNA/gene containing instructions for making a useful protein is packaged within a vector, usually a virus?bacterium? or plasmid?.
·                     The vector acts as a vehicle to carry the new DNA into the cells of a patient with a genetic disease.
·                     Once inside the cells of the patient, the DNA/gene is expressed by the cell’s normal machinery leading to production of the therapeutic protein and treatment of the patient’s disease.

Challenges of gene therapy
  • ·    Delivering the gene to the right place and switching it on:
  •          It is crucial that the new gene reaches the right cell
  •        Delivering a gene into the wrong cell would be inefficient and could also cause health problems for the patient
  •  Even once the right cell has been targeted the gene has to be turned on
  •  Cells sometimes obstruct this process by shutting down genes that are showing unusual activity.

  Avoiding the immune response:
  •       The role of the immune system is to fight off intruders.
  •    Sometimes new genes introduced by gene therapy are considered potentially-harmful intruders.
  •     This can spark an immune response in the patient, that could be harmful to them.
  •        Scientists therefore have the challenge of finding a way to deliver genes without the immune system ‘noticing’.
  •          This is usually by using vectors that are less likely to trigger an immune response.
  • ·     Making sure the new gene doesn’t disrupt the function of other genes:
  •         Ideally, a new gene introduced by gene therapy will integrate itself into the genome of the patient and continue working for the rest of their lives.
  •      There is a risk that the new gene will insert itself into the path of another gene, disrupting its activity. 
  •       This could have damaging effects, for example, if it interferes with an important gene involved in regulating cell division, it could result in cancer.

·   The cost of gene therapy:
  •         Many genetic disorders that can be targeted with gene therapy are extremely rare
  •          Gene therapy therefore often requires an individual, case-by-case approach. This may be effective, but may also be very expensive.


What is genetic engineering,How does genetic engineering work,The genetic engineering process,What else is genetic engineering used for,Alzheimer’s disease and the worm,What is a GMO,How do we make GMOs,

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What is genetic engineering?
·                     Genetic engineering, sometimes called genetic modification, is the process of altering the DNA? in an organism’s genome?.
·                     This may mean changing one base pair? (A-T or C-G), deleting a whole region of DNA, or introducing an additional copy of a gene?.
·                     It may also mean extracting DNA from another organism’s genome and combining it with the DNA of that individual.
·                     Genetic engineering is used by scientists to enhance or modify the characteristics of an individual organism.
·                     Genetic engineering can be applied to any organism, from a virus? to a sheep.
·                      For example, genetic engineering can be used to produce plants that have a higher nutritional value or can tolerate exposure to herbicides.

How does genetic engineering work?

To help explain the process of genetic engineering we have taken the example of insulin, a protein? that helps regulate the sugar levels in our blood.
·                     Normally insulin? is produced in the pancreas?, but in people with type 1 diabetes? there is a problem with insulin production.
·                     People with diabetes therefore have to inject insulin to control their blood sugar levels. 
·                     Genetic engineering has been used to produce a type of insulin, very similar to our own, from yeast and bacteria? like E. coli?
·                     This genetically modified insulin, ‘Humulin’ was licensed for human use in 1982. 

The genetic engineering process

1.                  A small piece of circular DNA called a plasmid? is extracted from the bacteria or yeast cell.
2.                A small section is then cut out of the circular plasmid by restriction enzymes, ‘molecular scissors’.
3.                The gene for human insulin is inserted into the gap in the plasmid. This plasmid is now genetically modified.
4.                The genetically modified plasmid is introduced into a new bacteria or yeast cell.
5.                 This cell then divides rapidly and starts making insulin.
6.                To create large amounts of the cells, the genetically modified bacteria or yeast are grown in large fermentation vessels that contain all the nutrients they need. The more the cells divide, the more insulin is produced.
7.                 When fermentation is complete, the mixture is filtered to release the insulin.
8.                The insulin is then purified and packaged into bottles and insulin pens for distribution to patients with diabetes.
What else is genetic engineering used for?
·                     The first genetically modified organism to be created was a bacterium, in 1973.
·                     In 1974, the same techniques were applied to mice.
·                     In 1994 the first genetically modified foods were made available.
·                     Genetic engineering has a number of useful applications, including scientific research, agriculture and technology.
·                     In plants, genetic engineering has been applied to improve the resilience, nutritional value and growth rate of crops such as potatoes, tomatoes and rice.
·                     In animals it has been used to develop sheep that produce a therapeutic protein in their milk that can be used to treat cystic fibrosis, or worms that glow in the dark to allow scientists to learn more about diseases such as Alzheimer’s?.

Alzheimer’s disease and the worm

·                     The nematode worm, C. elegans, only has around 300 cells in its entire nervous system, making it a very simple model for studying Alzheimer’s disease.
·                     Also, due to the fact the worm is nearly transparent, when their nerve cells are labelled with green fluorescent protein (GFP), it is possible to watch the location and activity of various structures and proteins under the microscope.
·                     The genetic material of C. elegans can easily be genetically modified to make the worm produce specific proteins the researchers want to study.
·                     In humans, the APP gene codes for a protein associated with the amyloid plaques that are characteristic of people with Alzheimer’s disease.
·                     So, to study Alzheimer’s, the researchers genetically engineered the nerve cells of the worm to contain the APP gene, effectively giving it Alzheimer’s.
·                     By tagging the APP protein produced in the worm with green fluorescent protein it was possible to see that all the cells that made contact with APP died as the worm got older.
·                     The researchers were then able to monitor the progression of Alzheimer’s disease in the worm and go on to apply their findings to understanding the role of APP in humans with Alzheimer’s disease.  

What is a GMO?
GMOs are organisms that have had their characteristics changed through the modification of their DNA.
·    GMO stands for genetically modified organism
Genetically modified (GM) organisms are organisms that have had their genomes? changed in a way that does not happen naturally.By changing an organism’s genome we can change its characteristics.Any organism could be genetically modified, but laws restrict the creation of genetically modified humans, and the production and distribution of other GMOs is tightly regulated.Common examples of GMOs are GM crops used in agriculture and GM model organisms? used in medical research.
How do we make GMOs?
·                     To create a GMO, we change specific characteristics by using lab techniques to delete or alter particular sections of DNA?.
·                     We can also change an organism’s characteristics by introducing new pieces of DNA into their genomes. This could be:
o                  DNA taken from the same species?
o                  DNA taken from a different species
o                  DNA made synthetically in the lab.
·                     The process of creating GMOs is called genetic modification or genetic engineering.
·                     There are several techniques that can be used to modify a genome:
o                  'Agrobacterium-mediated' genetic modification is a technique used to introduce new DNA into a plant genome using a modified microbe?.
o                  'Gene targeting' is a technique used to introduce new DNA into selected regions of a genome through a process called homologous recombination?.
o                  'Genome editing' is a technique used to change selected regions of a genome using enzymes? designed to cut specific DNA sequences?.
Why do we make GMOs?
·                     GMOs are generally made for medical, environmental, or commercial reasons.
o                  GM white mushrooms have had a gene? that normally causes them to go brown altered so it no longer functions. These mushrooms take longer to go brown, prolonging their shelf-life.
o                  GM bacteria? have been developed that have had a gene for insulin? added to their genome. These bacteria produce large quantities of insulin as they grow, which is then extracted and used by people with diabetes? to control their blood sugar levels.
o                   The Acer1 gene is thought to be involved in skin diseases like psoriasis. GM mice have been made where the Acer1 gene no longer functions to study what it normally does. These mice have hair loss and are less able to control heat and water loss from their skin.

HOW Technology useful in EDUCATION. Advantages and Disadvantages of Technology in Education

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HOW Technology useful in EDUCATION. Advantages and Disadvantages of Technology in Education

The modern classroom has taken several steps forward in its evolution of the learning environment in the past 25 years. Many of the benefits that we have seen in this setting are due to the introduction of new technology options for students. Instead of having a single computer for a class to use or a laboratory environment for the entire school placed in one room, we can now help students learn at their table or desk with items issued to them directly.
Our development of the Internet since 1989 has helped us to include more technological access to information in the modern classroom as well. If you grew up as an 80’s kid, then you had the A/V cart come into your class to watch educational videos and maybe have a snack. Now students get to play interactive learning games, compete against other students, and have their educational statistics tracked in real-time data to know where their point of focus should be.
Introducing technology to students in a classroom setting can certainly help the educational environment, but it also requires equal access for all students to ensure that everyone receives the same opportunities to success. That is why each school district, teacher, and parent should periodically review the advantages and disadvantages of technology in education settings.

List of the Advantages of Technology in Education

1. Technology helps children to stay motivated during the learning process.
Most students don’t like to go to school if they feel like they are wasting their time. When there is technology allowed in the classroom, then teachers have an opportunity to let kids work at a pace which suits them the best without disturbing others. They can look up additional information about a subject they are learning about that day, play educational games that reinforce the lesson, or work on advanced material using a program like Zearn.

Because many of today’s technology options allow students to see how well they are doing compared to the average of all users, it gives them a chance to push harder for themselves and their education. Many of the programs that encourage learning also issue rewards or award certificates, which helps to make the lessons fun as well.
2. It encourages more communication between teachers and parents.
When there is technology in the classroom, then there are more opportunities for parents and teachers to connect with each other. Using a blog for the classroom can help parents get to see what their children are learning each day. Apps and software options allow teachers to instantly report on a child’s behavior to let parents know in real-time what is happening throughout the day. There are options for chat boxes, instant messaging, and other forms of communication as well.

Let’s not forget about email here either. Since the 1990s when this technology option came into the classroom, it created more reliability in messaging between teachers and parents should there be a need to talk.
3. Technology options in the classroom are very affordable.
Although the cost of having technology in the classroom can be significant if you are introducing new options to an entire district, the cost of student computers, tablets, and class essentials is minimal. Most student computers cost less than $200 each, and there are several grants available on local, state, and national levels that help to offset these costs to local taxpayers.

“The Internet is the first technology since the printing press which could lower the cost of a great education and, in doing so, make the cost-benefit analysis much easier for most students,” said John Katzman. “It could allow American schools to serve twice as many students as they do now, and in ways that are both effective and cost-effective.”
4. It creates new ways to learn for today’s student.
There are three critical forms of intelligence that we see in children today: emotional, creative, and instructional. The traditional classroom environment, which typically encourages lecture-based lessons, focuses more on the latter option. Standardized tests and similar ranking tools do the same. When kids have access to technology today, then those who excel outside of the standard learning setup can still achieve their full potential.

Technology allows children to embrace their curiosity in multiple ways. They can try new things without embarrassment because their tech access gives them a level of anonymity. This process allows kids to work, through trial-and error if they wish, to see if a different strategy helps them to learn more effectively.
5. Technology allows us to give students access to data from a single location.
Do you remember when a research project meant a visit to the library so that you could pull 4-5 books to read, have access to an encyclopedia, and even microfilm to view so that you had enough resources to finish your assignment? Technology allows a student to access every item they need for a project from a central resource. Instead of spending all of that time searching for something specific or waiting for your library to order it, you can run a few queries on Google and find what you need.

6. It gives us better access to behavioral data on students.
The various apps, software choices, and technological platforms collect data on students that can show attendance patterns, learning issues in specific subjects, and how they react in particular situations. This information leads to the creation of a profile where teachers, schools, and parents can work together to identify places where additional learning may be necessary. Technology can even help a school district find their highly capable students to keep pushing them toward more challenging work so that they remain engaged with the learning environment.

7. Technology helps to prepare students for their future world.
Even if there are warnings from medical providers about the amount of screen time that students receive in their classroom environment, the reality of the modern educational system is that we must have technology exposure now to prepare our children for the world they will face as adults. This sector will continue to evolve. If they are not prepared to use these items today, then tomorrow could be a struggle for them.

That means some traditional subjects might not be as important to teach for some schools or teachers. Is it more important to have a student learn how to write in cursive or know how to type without using the two-finger chicken-pecking method? Is coding more of a critical skill than learning how to cook? Should kids know how to put a chair together in woodshop or have the ability to put together their own computer?
These are the questions we need to be asking when looking at the advantages and disadvantages of technology in the classroom.
8. The introduction of technology allows for the teaching of needed vocational skills.
Although there are regions of extreme poverty and isolation which do not have Internet access in the United States right now, over 90% of Americans have a home connection to online resources. By introducing technology to students from an early age, we can teach them the critical vocational skills that are necessary for success in a digital world. That is why writing continues to be a top priority in the K-4 grades, formatting guidelines and software use after, and knowing how to research efficiently is approached as an essential skill.

9. Technology in the classroom encourages collaboration.
Students retain very little of the information they receive when a teacher lectures from a textbook. When there are interactive lessons on a chalkboard or whiteboard, kids can remember about 20% of what they were taught. If a teacher encourages a small group discussion, that percentage can quadruple.

Technology gives us an easy way to develop collaboration skills for students using online tools that encourage them to work together in safe ways. If kids can then practice what they were taught immediately, there is very little that they will forget.
10. It encourages students to stay engaged with their learning environment.
Kids get bored very easily when they feel like they already know what is being taught in their classroom. Some children will transform into mentors or leaders in this situation to help their fellow students, but there are many more who disengage because they lack stimulation. By introducing technology to the classroom, there are fewer places where repetitive learning must take place. Teachers can introduce new subjects, try new techniques, or use different projects to encourage ongoing learning, which creates more overall engagement.

11. Teachers have more credibility when they use technology in the classroom.
Teachers are sometimes hesitant to use technology in the classroom because they are unsure of what a student might have at home. Giving homework assignments that require computer access to a student without that technology at home would be a waste of time. There can also be pushback from parents who are uncomfortable giving their kids additional screen time for learning. When you can introduce these elements to the classroom and have children learn there, then you can overcome the socioeconomic barriers that are sometimes in place for low-income families.

List of the Disadvantages of Technology in Education

1. The presence of technology can be distracting to students.
When kids play video games, they can find themselves reacting with addiction-like behaviors. Their focus is on the entertainment they receive more than anything else. If the educational environment uses reward-based games to encourage learning, then the child might be more concerned with what they receive through the software or app instead of what they are learning.

Although correct answers can be an indication of knowledge, there might not be as much information retention as hoped. Teachers must set and enforce healthy boundaries when using technology in the classroom to ensure healthy results are possible.
2. Technology can make it easier to cheat.
Remember the TV shows and movies where kids would break into a teacher’s classroom, steal the answer key to a test, and then write down everything on their wrist, shoe, or a slip of paper? Now a student can send themselves a text with that information. They can send that data to anyone else with a phone. Email can relay this info too. There must also be strict rules in place about the use of technology during quizzes or tests when an exact measurement of student knowledge is needed to evaluate their overall progress.

3. Using tech can cause some students to disconnect from the classroom.
Interacting online with others is a different experience than when you collaborate over the Internet with someone. Being behind a screen provides you with a layer of anonymity that you don’t receive with a face-to-face conversation. Learning how to work with one another using technology is an essential skill, but it cannot be the other option that teachers introduce to their classroom. We must encourage social interactions that accurately communicate thoughts, feelings, or emotions so that when a child is offline, they can still make a better life for themselves.

4. Some students may not know the difference between reliable and unreliable resources.
There is a lot of information on the Internet today that is fake or exaggerated in some way, but it masquerades as being real. According to research published by New York Magazine, less than 60% of web traffic today is actually human-based searches or content interaction. Up to half of the traffic on YouTube each year are bots that masquerade as people. Not only is the content sometimes fake, but then also the users might not be real too. Teachers must show students how to access real information, show them how to verify its validity, and then encourage them to use it appropriately.

5. Technology is a resource that not all families can afford.
Whether technology is in the classroom or at home, there is the issue of affordability to worry about in today’s world. Some households cannot afford to purchase computers for their kids to manage their school work. There are school districts that don’t have enough money to pay their salaries each year, much less add new tech components for learning.

When we emphasize having technology in the classroom, then we place those at the lowest end of the wage scale at a significant disadvantage. Students with greater access can learn more and have access to lessons more often, which means they have additional information exposure that can increase their opportunities to succeed.
6. Some technologies could replace the teacher in some classrooms.
Interactive learning lessons are so effective today that the software or app can become the teacher instead of having someone present to help a student. One of the best examples of this potential disadvantage is ABC Mouse, which provides clear instructions to students as young as 3 so that they can start learning when they are ready.

Instead of being in a hands-on role, technology makes the teacher more of an observer. New tech automates the learning process while adapting to changing student needs.
7. There are privacy concerns to consider with technology in the classroom.
Over 15 million people each year experience identity theft in some way. It is a criminal empire that costs the economy over $16 billion per year. Since 2011, over $100 billion in losses have happened because of this issue. One of the reasons why it is becoming more prevalent is because more people have greater access to technology today.

When we introduce technology to the classroom, we are placing the identity of our children at risk every day. Even when apps, computers, mobile devices, and operating systems have advanced privacy filters that reduce the threat of identity loss, there is no way to guarantee that all risks are gone unless the equipment never goes online. If we take this step, then we end up losing many of the advantages of having technology in the classroom in the first place.
8. Technology in the classroom could create medical problems for some kids.
Eye strain occurs when you look at a computer screen for too long. Symptoms of this issue include back pain, eye pain, neck pain, feelings of tiredness, blurred vision, and problems with focus. Continuous heavy computer usage may lead to issues with early myopia, with a prevalence rate of more than 60% for those older than the age of 12. For some people, the impact of this health issue is cumulative, which means the time they spend in front of a phone, tablet, and television can contribute to eye health issues as well.

9. Kids often lose track of time when using technology in the classroom.
Although kids can adapt to changing environments without much of a second thought, their idea of normal is often defined by what they experience in the classroom. Teachers and schools have as much, if not more, time with children than their parents throughout the day, which means the classroom becomes an influential part of life for each student. Encouraging the use of tech might help to create more learning opportunities, but it can also lead to a lifestyle that is more sedentary.

When children sit for too long during the day, then they face the same health challenges that adults do when not getting enough exercise. There can be problems with obesity, hyperactivity, muscle fatigue, sleeping problems, and metabolism issues with prolonged sitting. That is why any school that introduces technology to the classroom should also encourage at least 30 minutes of moderate physical activity whenever possible.
10. Many classrooms place limits on technology access.
Because of the awareness that schools have with the potential disadvantages that technology can cause in the classroom, there are limits placed on the use of items under the guise of child protection. Although firewalls and site blockers can prevent most dangerous content from reaching the eyes of children, it is not unusual to see this issue taken a step further by restricting computer work to word processing and basic research. Students come home with assignments to use tech of their own, at a library, or through a loan program to place this responsibility on the parents instead.

If we force limits on children instead of teaching them how to make wise choices, then is that really giving them a learning environment?
11. Technology can create dependencies for information recall.
If you cannot recall a piece of information instantly, then what is your next step to find an answer? Most people would say that they would look online for the data they want or ask a virtual assistant, like Alexa, to give them the answer. Having access to a treasure-trove of resources is wonderful, but it can also create a dependency because of its presence. If we do not teach students how to recall info by themselves without the use of a smart device or computer, then the next generation of students may be unable to function unless there is technology for them to access.

Verdict on the Advantages and Disadvantages of Technology in the Classroom

These advantages and disadvantages of technology in the classroom indicate that students and teachers can be more effective in their roles with its presence. Although there can be varying levels of comfort based on the amount of exposure each person has to computers, electronic whiteboards, and other items, an introduction of new tech is an investment that can offer ongoing dividends.
There are times when technology can provide new experiences to a student. Teachers can use apps and software to reach kids that might normally disconnect from the classroom.
Technology in the classroom opens more doors, introduces new experiences, and creates more opportunities for self-discovery. The positive aspects that occur with school integration typically outweigh any of the issues that a district might encounter


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